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Bioinstructive Implantable Scaffolds For Rapid In Vivo …

Despite their clinical success, chimeric antigen receptor (CAR)-T cell therapies for B cell malignancies are limited by lengthy, costly and labor-intensive ex vivo manufacturing procedures that might lead to cell products with heterogeneous composition. Here we describe an implantable Multifunctiona …

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(53 years ago) 9. Vitamin B-12 malabsorption and renal function are critical considerations in studies of folate and vitamin B-12 interactions in cognitive performance: NHANES 2011-2014. Samson ME, Yeung LF, Rose CE, Qi YP, Taylor CA, Crider KS. Samson ME, et al. Am J Clin Nutr. 2022 May 18:nqac065. doi: 10.1093/ajcn/nqac065.

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New-onset autoimmune phenomena post-COVID-19 …

(53 years ago) Recently, new-onset autoimmune phenomena after COVID-19 vaccination have been reported increasingly (e.g. immune thrombotic thrombocytopenia, autoimmune liver diseases, Guillain-Barré syndrome, IgA nephropathy, rheumatoid arthritis and systemic lupus erythematosus). Molecular mimicry, the production of particular autoantibodies and the role of ...

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Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults …

(53 years ago) Background: Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (M pro) inhibitor with potent pan-human-coronavirus activity in vitro. Methods: We conducted a phase 2-3 double-blind, randomized, controlled trial in which symptomatic, unvaccinated, nonhospitalized adults at high risk for progression to severe coronavirus …

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mRNA vaccines for infectious diseases: principles, delivery …

(53 years ago) Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the most rapid vaccine development in history, with mRNA vaccines at the forefront of those efforts. Although it is now clear tha …

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About - PubMed - National Institutes of Health

(53 years ago) PubMed Overview. PubMed is a free resource supporting the search and retrieval of biomedical and life sciences literature with the aim of improving health–both globally and personally. The PubMed database contains more than 34 million citations and abstracts of biomedical literature. It does not include full text journal articles; however ...

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PubMed

(53 years ago) PubMed® comprises more than 34 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.

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Identification of antimicrobial peptides from the human …

(53 years ago) The human gut microbiome encodes a large variety of antimicrobial peptides (AMPs), but the short lengths of AMPs pose a challenge for computational prediction. Here we combined multiple natural language processing neural network models, including LSTM, Attention and BERT, to form a unified pipeline …

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Long-term effects of COVID-19 on mental health: A systematic …

(53 years ago) Nov 21, 2021 · The overall effect of the pandemic has been linked with worsening psychiatric symptoms. However, the long-term effect from direct COVID-19 infection has been associated with no or mild symptoms. Studies exhibited the long-term prevalence of anxiety, depression, PTSD, and sleep disturbances to be com …

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Primary Pandemic Prevention - PubMed

(53 years ago) Over the last few decades, hundreds of human pathogens have emerged at a rate unprecedented in human history. Emerged from where? Mostly from animals. The AIDS virus is blamed on the butchering of primates in the African bushmeat trade, we created mad cow disease when we turned cows into carnivores …

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Antibiotics for the treatment of COVID-19 - PubMed

(53 years ago) The use of antibiotics follows the intention-to-treat the viral disease and not primarily to treat bacterial co-infections of individuals with COVID-19. A thorough understanding of the current evidence regarding effectiveness and safety of antibiotics as anti-viral treatments for COVID-19 based on randomised controlled trials (RCTs) is required.

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Features, Evaluation, and Treatment of Coronavirus (COVID-19)

(53 years ago) Feb 05, 2022 · Excerpt. Coronavirus disease 2019 (COVID-19), the highly contagious viral illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a catastrophic effect on the world’s demographics resulting in more than 3.8 million deaths worldwide, emerging as the most consequential global health crisis since the era of the ...

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Inhibition of METTL3 attenuates renal injury and inflammation by ...

(53 years ago) The role of N 6-methyladenosine (m6A) modifications in renal diseases is largely unknown.Here, we characterized the role of N 6-adenosine-methyltransferase-like 3 (METTL3), whose expression is elevated in renal tubules in different acute kidney injury (AKI) models as well as in human biopsies and cultured tubular epithelial cells (TECs). METTL3 silencing alleviated renal …

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Evaluating the Association Between Low-Density Lipoprotein …

(53 years ago) Importance: The association between statin-induced reduction in low-density lipoprotein cholesterol (LDL-C) levels and the absolute risk reduction of individual, rather than composite, outcomes, such as all-cause mortality, myocardial infarction, or stroke, is unclear. Objective: To assess the association between absolute reductions in LDL-C levels with treatment with statin …

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Duration of effectiveness of vaccines against SARS-CoV-2 infection …

(53 years ago) Background: Knowing whether COVID-19 vaccine effectiveness wanes is crucial for informing vaccine policy, such as the need for and timing of booster doses. We aimed to systematically review the evidence for the duration of protection of COVID-19 vaccines against various clinical outcomes, and to assess changes in the rates of breakthrough infection caused by the delta …

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Wound healing and wound care - PubMed

(53 years ago) Wound healing and wound care Scott Med J. 1960 Jul;5:279-89. doi: 10.1177/003693306000500701. Author

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The potential neurological effect of the COVID-19 vaccines: A review

(53 years ago) The reported severe adverse effects raised the worries about their safety. It becomes critical to know whether these vaccines will cause neurologic disorders like previously recognized vaccine-related demyelinating diseases, fever-induced seizure, and other possible deficits. We reviewed the most promising COVID-2 vaccines with a particular ...

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Tumor-reactive antibodies evolve from non-binding and …

(53 years ago) The tumor microenvironment hosts antibody-secreting cells (ASCs) associated with a favorable prognosis in several types of cancer. Patient-derived antibodies have diagnostic and therapeutic potential; yet, it remains unclear how antibodies gain autoreactivity and target tumors. Here, we …

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Emerging Variants of SARS-CoV-2 And Novel Therapeutics Against ...

(53 years ago) Feb 06, 2022 · Coronavirus disease 2019 (COVID-19), the illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a devastating effect on the world’s population resulting in more than 5.4 million deaths worldwide and emerging as the most significant global health crisis since the influenza pandemic of 1918.

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Early assessment of the clinical severity of the SARS-CoV-2 …

(53 years ago) Background: The SARS-CoV-2 omicron variant of concern was identified in South Africa in November, 2021, and was associated with an increase in COVID-19 cases. We aimed to assess the clinical severity of infections with the omicron variant using S gene target failure (SGTF) on the Thermo Fisher Scientific TaqPath COVID-19 PCR test as a proxy.

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COVID-19: A Review on the Novel Coronavirus Disease Evolution ...

(53 years ago) Three major outbreaks of the coronavirus, a zoonotic virus known to cause respiratory disease, have been reported since 2002, including SARS-CoV, MERS-CoV and the most recent 2019-nCoV, or more recently known as SARS-CoV-2. Bats are known to be the primary animal reservoir for coronaviruses. However …

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Immune imprinting, breadth of variant recognition, and germinal …

(53 years ago) During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been deployed globally. We investigated whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated by infection or adenoviral (ChAdOx1-S and Gam-COVID-Vac) or i …

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COVID-19 pandemic and mental health consequences: Systematic …

(53 years ago) The two studies investigating COVID-19 patients found a high level of post-traumatic stress symptoms (PTSS) (96.2%) and significantly higher level of depressive symptoms (p = 0.016). Patients with preexisting psychiatric disorders reported worsening of psychiatric symptoms. Studies investigating health care workers found increased depression ...

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Effect of Sotrovimab on Hospitalization or Death Among High-risk ...

(53 years ago) Importance: Older patients and those with comorbidities who are infected with SARS-CoV-2 may be at increased risk of hospitalization and death. Sotrovimab is a neutralizing antibody for the treatment of high-risk patients to prevent COVID-19 progression. Objective: To evaluate the efficacy and adverse events of sotrovimab in preventing progression of mild to moderate …

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Nirsevimab for Prevention of RSV in Healthy Late-Preterm and …

(53 years ago) Mar 03, 2022 · Background: Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection and hospitalization in infants. Nirsevimab is a monoclonal antibody to the RSV fusion protein that has an extended half-life. The efficacy and safety of nirsevimab in healthy late-preterm and term infants are uncertain.

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Pneumonia - PubMed - National Institutes of Health

(53 years ago) Pneumonia is a common acute respiratory infection that affects the alveoli and distal airways; it is a major health problem and associated with high morbidity and short-term and long-term mortality in all age groups worldwide. Pneumonia is broadly …

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COVID-19: a review - PubMed

(53 years ago) Abstract. The enduring epidemic outbreak which started in Wuhan city of China, in December 2019 caused by the 2019 novel coronavirus (COVID- 19) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a dangerous and deadly Public Health disaster of International apprehension, with cases confirmed in several countries.

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The epidemiology and pathogenesis of coronavirus disease …

(53 years ago) Abstract. Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. Based on the large number of infected people that were exposed to the wet animal market in Wuhan City, China, it is suggested that this is likely the zoonotic origin of ...

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Searching the MEDLINE literature database through PubMed: a …

(53 years ago) The Medline database from the National Library of Medicine (NLM) contains more than 12 million bibliographic citations from over 4,600 international biomedical journals. One of the interfaces for searching Medline is PubMed, provided by the NLM for free access via the Internet (www.pubmed.gov). Also searchable with the PubMed interface are non ...

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Searching NCBI Databases Using Entrez - PubMed

(53 years ago) One of the most widely used interfaces for the retrieval of information from biological databases is the NCBI Entrez system. Entrez capitalizes on the fact that there are pre-existing, logical relationships between the individual entries found in numerous public databases. The existence of such natural connections, mostly biological in nature ...

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Coping During the COVID-19 Pandemic: A Qualitative Study of …

(53 years ago) Methods: The COVID-19 Coping Study recruited 6,938 adults aged ≥55 through online multi-frame sampling from April 2-May 31, 2020 across all 50 US states, the District of Columbia, and Puerto Rico. The online questionnaire focused on the effects of COVID-19 on daily life, mental health, and well-being. This included an open-ended question ...

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Decline in the mental health of nurses across the globe during …

(53 years ago) Background: Nurses represent the major proportion of frontline health care professionals delivering 24/7 services to patients with an increased vulnerability towards COVID-19 infection. Mental health issues among nurses during the COVID-19 pandemic are poorly reported across the globe. Henceforth, a systematic review and meta-analysis was performed to explore the …

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The Coronavirus Disease 2019 (COVID-19) Pandemic - PubMed

(53 years ago) The present study provides an overview of the coronavirus disease 2019 (COVID-19) outbreak which has rapidly extended globally within a short period. COVID-19 is a highly infectious respiratory disease caused by a new coronavirus known as SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2). …

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Probiotics - PubMed

(53 years ago) Purpose: The pharmacology, uses, dosages, safety, drug interactions, and contraindications of probiotics are reviewed. Summary: Probiotics are live nonpathogenic microorganisms administered to improve microbial balance, particularly in the gastrointestinal tract. They consist of Saccharomyces boulardii yeast or lactic acid bacteria, such as Lactobacillus and …

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The SARS-CoV-2 Nucleocapsid Protein and Its Role in Viral …

(53 years ago) The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world is still expanding. Thus, there is an urgent need to better understand this novel virus and find a way to control its spread. Like other coronaviruses, the nucleocapsid (N) protein is …

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Hypothyroidism - PubMed

(53 years ago) Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate.

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